Platelets Specifically Accumulate At The Site Of Liver Regeneration And Stimulate Interleukine-6 Production In Sinusoidal Endothelial Cells
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چکیده
منابع مشابه
Liver sinusoidal endothelial cells and liver regeneration.
Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic stellate cell, but after liver injury, HGF expression has been thought to increase markedly in proliferating LSECs. However, emerging data suggest that even after injury, LSEC expression of HGF does not increase ...
متن کاملLiver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats.
The ability of the liver to regenerate is crucial to protect liver function after injury and during chronic disease. Increases in hepatocyte growth factor (HGF) in liver sinusoidal endothelial cells (LSECs) are thought to drive liver regeneration. However, in contrast to endothelial progenitor cells, mature LSECs express little HGF. Therefore, we sought to establish in rats whether liver injury...
متن کاملPathological process of liver sinusoidal endothelial cells in liver diseases
Cirrhosis develops from liver fibrosis and is the severe pathological stage of all chronic liver injury. Cirrhosis caused by hepatitis B virus and hepatitis C virus infection is especially common. Liver fibrosis and cirrhosis involve excess production of extracellular matrix, which is closely related to liver sinusoidal endothelial cells (LSECs). Damaged LSECs can synthesize transforming growth...
متن کامل[Platelets and liver regeneration].
Platelets are the smallest structures in circulating blood and have a convex disc construction with an equatorial diameter of 2-3 microns and have no nucleus. They are derived from megakaryocytes in the bone marrow. Following their normal life span of 8-10 days, they are removed from the circulation when passing through the spleen. Platelets have three types of secretory granules, i.e., alpha-g...
متن کاملLiver sinusoidal endothelial cells are the principal site for elimination of unfractionated heparin from the circulation.
The mechanism of elimination of blood borne heparin was studied. To this end unfractionated heparin (UFH) was tagged with FITC, which served as both a visual marker and a site of labeling with (125)I-iodine. UFH labeled in this manner did not alter the anticoagulant activity or binding specificity of the glycosaminoglycan. Labeled heparin administered intravenously to rats (0.1 IU/kg) had a cir...
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ژورنال
عنوان ژورنال: HPB
سال: 2020
ISSN: 1365-182X
DOI: 10.1016/j.hpb.2020.04.860